Perfluorocarbon‐Based 19 F MRI Nanoprobes for In Vivo Multicolor Imaging
| Autor: | Hisashi Matsushita, Shin Mizukami, Hiroaki Mukai, Tatsuya Nakamura, Rena Akimoto, Fuminori Sugihara, Kazuya Kikuchi, Masafumi Minoshima, Kazuki Akazawa |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.diagnostic_test
010405 organic chemistry Chemistry Magnetic resonance imaging General Medicine 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Catalysis 0104 chemical sciences Silica nanoparticles Nuclear magnetic resonance In vivo embryonic structures Imaging technology medicine Proton NMR 0210 nano-technology Preclinical imaging |
| Zdroj: | Angewandte Chemie International Edition. 57:16742-16747 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201810363 |
| Popis: | In vivo multicolor imaging is important for monitoring multiple biomolecular or cellular processes in biology. 19 F magnetic resonance imaging (MRI) is an emerging in vivo imaging technique because it can non-invasively visualize 19 F nuclei without endogenous background signals. Therefore, 19 F MRI probes capable of multicolor imaging are in high demand. Herein, we report five types of perfluorocarbon-encapsulated silica nanoparticles that show 19 F NMR peaks with different chemical shifts. Three of the nanoprobes, which show spectrally distinct 19 F NMR peaks with sufficient sensitivity, were selected for in vivo multicolor 19 F MRI. The nanoprobes exhibited 19 F MRI signals with three colors in a living mouse. Our in vivo multicolor system could be utilized for evaluating the effect of surface functional groups on the hepatic uptake in a mouse. This novel multicolor imaging technology will be a practical tool for elucidating in vivo biomolecular networks by 19 F MRI. |
| Databáze: | OpenAIRE |
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