Social participation in patients with multiple sclerosis: correlations between disability and economic burden
| Autor: | Patrick Hautecoeur, Benoît Dervaux, Arnaud Kwiatkowski, Madani Pouyfaucon, Patrick Vermersch, Jean-Pierre Marissal |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Gerontology
Quality of life Adult Employment Male medicine.medical_specialty Multiple Sclerosis Clinical Neurology Economic burden Antibodies Monoclonal Humanized Disability Evaluation Natalizumab Cost of Illness Economic cost medicine Humans In patient Social Behavior Expanded Disability Status Scale business.industry Multiple sclerosis General Medicine Social participation Middle Aged Social engagement medicine.disease humanities Personal Autonomy Physical therapy Female Neurology (clinical) business Medical costs Immunosuppressive Agents medicine.drug Research Article |
| Zdroj: | BMC Neurology |
| ISSN: | 1471-2377 |
| Popis: | Background Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwMS). Methods We interviewed 42 pwMS receiving natalizumab and collected clinical data, direct medical costs, productivity loss, utility (EQ5D-VAS), MS-specific QOL (SEP-59), social participation with the Impact on Participation and Autonomy questionnaire (IPA). We performed descriptive and correlation analyses. Results 41 pwMS, with a mean Expanded Disability Status Scale (EDSS) score of 4.0, completed questionnaires. Mean annual global cost per patient was 68448 +/-33374 Euros and increased with EDSS (r = 0.644), utility (r = -0.456) and IPA (r = 0.519-0.671) worsening. Mean utility was 0.52 +/- 0.28. Correlations between IPA and QOL (EQ5D-VAS or SEP-59) were observed (r = -0.53 to -0.78). Association between QOL and EDSS was smaller (EQ5D-VAS) or absent. Productivity losses were poorly correlated to EDSS (r = 0.375). Conclusion Moderate to strong correlations of social participation with clinical status (EDSS), QOL, utility and economic costs encourage exploring better these links in larger cohorts. The stronger correlation between social participation and QOL than between EDSS and QOL needs to be confirmed. |
| Databáze: | OpenAIRE |
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