Newly described translocation (18;19)(q23;q13.2) in abdominal wall soft-tissue tumor resembling Ewing sarcoma/primitive neuroectodermal tumor
| Autor: | Timothy A. Damron, Constance K. Stein, Gina F. Riccardi, Gustavo de la Roza |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Adolescent Cell Neuroectodermal Tumors Chromosomal translocation Soft Tissue Neoplasms Sarcoma Ewing Biology Translocation Genetic Abdominal wall Genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Proto-Oncogene Protein c-fli-1 Breakpoint Soft tissue RNA-Binding Proteins Anatomy medicine.disease medicine.anatomical_structure FLI1 Primitive neuroectodermal tumor Abdominal Neoplasms Karyotyping Calmodulin-Binding Proteins Sarcoma RNA-Binding Protein EWS Chromosomes Human Pair 18 Chromosomes Human Pair 19 |
| Zdroj: | Cancer genetics and cytogenetics. 201(1) |
| ISSN: | 1873-4456 |
| Popis: | From a morphologic standpoint, Ewing sarcoma (EWS) is one of a number of pediatric malignancies that are characterized by sheets of small, round, blue cells. Ewing sarcoma can usually be differentiated from other small round blue cell tumors by the presence of a gene rearrangement having a consistent breakpoint within the Ewing sarcoma gene (EWSR1) at 22q12. Although the most common translocation partner is FLI1, located at 11q24, there is a growing list of alternate rearrangements involving different loci. We describe the first example of a soft-tissue sarcoma morphologically and immunohistochemically similar to Ewing sarcoma, but with a novel t(18;19)(q23;q13.2). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect