The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk
Autor: | Gary J. Farkas, Janet Konefal, Eduard Tiozzo, John E. Lewis, Allan Rodriguez, Jennifer L. Maher |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Blood Glucose
medicine.medical_specialty Diabetes risk Health Toxicology and Mutagenesis Human immunodeficiency virus (HIV) lcsh:Medicine 030209 endocrinology & metabolism HIV Infections Type 2 diabetes Carbohydrate metabolism medicine.disease_cause Fasting insulin Article HOMA-IR 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine insulin resistance Medicine Humans Insulin 030212 general & internal medicine business.industry lcsh:R Public Health Environmental and Occupational Health Type 2 Diabetes Mellitus duration medicine.disease HIV infection Obesity Cross-Sectional Studies Diabetes Mellitus Type 2 Female type 2 diabetes business |
Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 3926, p 3926 (2021) International Journal of Environmental Research and Public Health Volume 18 Issue 8 |
ISSN: | 1661-7827 1660-4601 |
Popis: | The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (n = 34), those with longer HIV duration (n = 48) were on average older (p = 0.02), reported lower consumption of alcohol (p = 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR, p = 0.02), were also more likely to be a woman (p = 0.06), and have higher levels of fasting insulin (p = 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (p = 0.02 and p = 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required. |
Databáze: | OpenAIRE |
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