Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

Autor: Lijuan Wang, Qunxian Rao, Zhongqiu Lin, Ni-ya Ning, Jing Li, Rong Chen
Rok vydání: 2017
Předmět:
Oncology
Blood Glucose
Cancer Research
medicine.medical_treatment
Uterine Cervical Neoplasms
Kaplan-Meier Estimate
0302 clinical medicine
Diabetes mellitus
Medicine
030212 general & internal medicine
Neoplasm Metastasis
Neoadjuvant therapy
Cervical cancer
Aged
80 and over
Hazard ratio
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Neoadjuvant Therapy
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Female
Research Article
Adult
medicine.medical_specialty
lcsh:RC254-282
Neoadjuvant chemotherapy
Diabetes Complications
03 medical and health sciences
Young Adult
Internal medicine
Genetics
Humans
Survival analysis
Glycemic
Aged
Neoplasm Staging
Proportional Hazards Models
Glycated Hemoglobin
business.industry
Proportional hazards model
Retrospective cohort study
Odds ratio
medicine.disease
Hemoglobin A1c
Neoplasm Grading
business
Biomarkers
Zdroj: BMC Cancer
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
ISSN: 1471-2407
Popis: Background To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer (LACC). Methods A retrospective cohort study was conducted to examine LACC patients undergoing NACT and radical hysterectomy between 2002 and 2011. Patients were divided into three groups: patients without diabetes mellitus (DM), diabetic patients with good glycemic control, and diabetic patients with poor glycemic control. Hemoglobin A1c (HbA1c) levels were used to indicate glycemic control status. Recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) were analyzed using log-rank tests and Cox proportional hazards models. Results In total, 388 patients were included and had a median follow-up time of 39 months (range: 4–67 months). Diabetes mellitus (DM) was diagnosed in 89 (22.9%) patients, only 35 (39.3%) of whom had good glycemic control prior to NACT (HbA1c
Databáze: OpenAIRE
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