De novo DNA Methylation: Who's Your DADdy?
| Autor: | Marla E. Tharp, Alex Bortvin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Transposable element
Male Heterochromatin Biology Genome Chromatin remodeling 03 medical and health sciences Mice 0302 clinical medicine Gonocyte Genetics medicine Animals 030304 developmental biology 0303 health sciences Methylation DNA Methylation Chromatin Cell biology medicine.anatomical_structure Germ Cells DNA methylation 030217 neurology & neurosurgery Germ cell |
| Zdroj: | Trends in genetics : TIG. 35(11) |
| ISSN: | 0168-9525 |
| Popis: | DNA methylation regulates the organization and function of the genome. Yamanaka et al. now report that de novo methylation of male germ cells of mice involves the transient opening of heterochromatin at megabase-size differentially accessible domains (DADs). This chromatin remodeling likely facilitates de novo methylation of the germ cell genome. |
| Databáze: | OpenAIRE |
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