Clinical epidemiology of chronic viral hepatitis B: A Tuscany real-word large-scale cohort study
| Autor: | Piero Colombatto, Cristina Stasi, Giampaolo Bresci, Alessandro Nerli, Anna Linda Zignego, D. Aquilini, Paolo Forte, Andrea Cozzi, Cristina Orsini, Silvia Chigiotti, Rodolfo Sacco, Sauro Luchi, Giampaolo Corti, Cesira Nencioni, Stefano Milani, Santino Marchi, Massimo Giusti, Angelo Ricchiuti, Caterina Silvestri, Silvia Carloppi, Roberto Berni, Andrea Galli, P. Almi, Paola Carrai, Francesco Cipriani, Ricciardi L, Franco Filipponi, Alessandro Bartoloni, Maurizia Rossana Brunetto, Pierluigi Blanc, Fabio Voller, Giacomo Laffi, Andrea De Luca |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pediatrics Cirrhosis Epidemiology Liver fibrosis Clinical epidemiology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Hepatitis B virus infection Retrospective Cohort Study Chronic viral hepatitis B Public health Hepatology business.industry medicine.disease 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Real word business Cohort study |
| Zdroj: | World Journal of Hepatology |
| Popis: | AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus (HBV)-infected patients in the Tuscan public health care system. METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096 (27.3%) were HBV infected. The case report form was correctly completed for only 833 patients (64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years (only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures (23%), mother-to-child (17%) and sexual transmission (12%). The most represented HBV genotypes were D (72%) and A (14%). Of the patients, 24.7% of patients were HBeAg positive, and 75.3% were HBeAg negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic (35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. |
| Databáze: | OpenAIRE |
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