3D analysis of facial morphology in Dutch children with cancer
| Autor: | Johannes H. M. Merks, Raoul C.M. Hennekam, Saskia M. J. Hopman, Floor A. M. Postema, Hanne Hoskens, Michael Suttie, Harold Matthews, Peter Hammond, Peter Claes, Hilde Peeters |
|---|---|
| Přispěvatelé: | General Paediatrics, APH - Quality of Care |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty 3d analysis Health Informatics Malignancy European descent 030218 nuclear medicine & medical imaging Imaging 03 medical and health sciences 0302 clinical medicine Imaging Three-Dimensional Neoplasms medicine Photography Humans Genetic risk Child Facial asymmetry business.industry Significant difference Facial morphology Cancer medicine.disease Computer Science Applications Face business Three-dimensional 030217 neurology & neurosurgery Software Facial symmetry |
| Zdroj: | Computer methods and programs in biomedicine, 205:106093. Elsevier Ireland Ltd |
| ISSN: | 0169-2607 |
| Popis: | UNLABELLED: Background and Objective; Genetic risk factors for childhood cancer may also influence facial morphology. 3D photography can be used in the recognition of differences in face shape among individuals. In previous research, 3D facial photography was used to identify increased facial asymmetry and greater deviation from normal facial morphology in a group of individuals with distinct morphological features who had childhood cancer compared to healthy controls. In this study, we aim to determine whether there is a difference in facial morphology between children with cancer without previously selected morphological features and healthy controls, detected with 3D facial photography. METHODS: Facial 3D photographic images were obtained of children with a newly diagnosed malignancy. The resulting sample comprised 13 different cancer types. Patients were excluded if they had a known genetic cause of the cancer. Patients were compared to healthy controls, matched for sex, age and ethnic background. The degree of asymmetry and overall deviation of an individual's face from an age and sex typical control face were measured. RESULTS: A total of 163 patients of European descent were included. No significant difference in asymmetry between patients and controls could be identified. On average, patients deviated more from an age and sex typical face than the controls. CONCLUSION: This study shows that children with cancer deviate more than controls, possibly suggesting a higher prevalence of genetic anomalies within this group. The results suggest that this is not sufficient to discriminate patients from controls. Further research is necessary to explore the patterns of individual variation among the overall deviation of patients and controls. The open access fees have been paid for this paper, so the paper is open-access in this normally closed-access journal ispartof: Computer Methods And Programs In Biomedicine vol:205 ispartof: location:Ireland status: Published online |
| Databáze: | OpenAIRE |
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