Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
| Autor: | Roberto Lamonega, Gabriel Orlandi, Mirta Berges, Adrian Tarditti, Maria Victoria Castuma, Cecilia Gardiner, Mercedes Portas, S. Bossi, Gustavo Roque, Silvia Scafatti, José María Tau, Eduardo Mansilla, Andrea Núñez, Sandra Pena Luengas, K. Martire, F. Sturla, Hugo Drago, Martin Menvielle, Jaime Rivas, Gustavo Horacio Marín |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Mesenchymal medicine.medical_treatment Biomedical Engineering INGENIERÍAS Y TECNOLOGÍAS Dermatology Critical Care and Intensive Care Medicine Regenerative medicine Immunology and Allergy Medicine Ingeniería Médica Transplantation business.industry Mesenchymal stem cell purl.org/becyt/ford/2.6 [https] Cadaveric Surgery Skin regeneration medicine.anatomical_structure purl.org/becyt/ford/2 [https] Escharotomy Emergency Medicine Mesenchymal stem cells Bone marrow Stem cell Burns business Cadaveric spasm Total body surface area Research Article |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Burns & Trauma |
| ISSN: | 2321-3876 |
| DOI: | 10.1186/s41038-015-0018-4 |
| Popis: | Background: In January 2005, Rasulov et al. originally published ?First experience in the use of bone marrowmesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns. Here, we present the firstever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns whileworking with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow ofa cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry ofHealth, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after earlyescharotomy.Results: So far, our preliminary experience and our early results have been very impressive showing an outstandingsafety data as well as some impressive good results in the use of CMSCs.Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in thenear future and a lot of time as well as many lives could be saved by many other research teams all over the world.CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation. Fil: Mansilla, Eduardo. No especifíca; Fil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Berges, Mirta. Hospital San Martin; Argentina Fil: Scafatti, Silvia. Hospital San Martin; Argentina Fil: Rivas, Jaime. Hospital San Martin; Argentina Fil: Núñez, Andrea. Hospital San Martin; Argentina Fil: Menvielle, Martin. Hospital San Martin; Argentina Fil: Lamonega, Roberto. Hospital San Martin; Argentina Fil: Gardiner, Cecilia. Hospital San Martin; Argentina Fil: Drago, Hugo. Hospital Burns; Argentina Fil: Sturla, Flavio. Hospital Burns; Argentina Fil: Portas, Mercedes. Hospital Burns; Argentina Fil: Bossi, Silvia. Hospital Burns; Argentina Fil: Castuma, Maria Victoria. No especifíca; Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto Rico Fil: Roque, Gustavo. No especifíca; Fil: Martire, Karina. No especifíca; Fil: Taulamet, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Orlandi, Gabriel. No especifíca; Fil: Tarditti, Adrian. No especifíca |
| Databáze: | OpenAIRE |
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