Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome
| Autor: | Francisco Epelde Gonzalo, Héctor Alonso Valle, Luis García-Castrillo Riesgo, Miguel Sántalo Bel, Luis Iglesias Oliva, Miguel Sánchez Sanchez |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Chest Pain Acute coronary syndrome medicine.medical_specialty Myocardial Infarction Fatty Acid-Binding Proteins Chest pain Sensitivity and Specificity Troponin T Internal medicine Humans Medicine Prospective Studies Myocardial infarction Acute Coronary Syndrome Aged business.industry Emergency department Middle Aged medicine.disease Heart-type fatty acid binding protein Emergency Medicine Cardiology Female lipids (amino acids peptides and proteins) Fatty Acid Binding Protein 3 Myocardial infarction diagnosis medicine.symptom Emergency Service Hospital business Biomarkers |
| Zdroj: | European Journal of Emergency Medicine. 15:140-144 |
| ISSN: | 0969-9546 |
| DOI: | 10.1097/mej.0b013e3282efd47a |
| Popis: | BACKGROUND Early identification of acute coronary syndrome (ACS) in the emergency room is still a difficult task. The objective of this study is to estimate the reliability of heart-type fatty acid binding protein (H-FABP) in identifying ACS in the early stage of chest pain onset. METHODS In a prospective multicentre study in emergency room patients with suspected ACS lasting less than 3 h, heart heart-type fatty acid binding protein (H-FABP) was compared with conventional biomarkers. Protein levels >7 ng/ml were considered positive results. RESULTS A total of 419 patients were analyzed. Acute myocardial infarction was diagnosed in 148 patients (35%). H-FABP sensitivity was 60% (89 out of 148 patients), significantly higher than troponin T [19% (28 out of 148 patients); P |
| Databáze: | OpenAIRE |
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