Brief Report: Increased Frequency of CD39+ CD56bright Natural Killer Cells in HIV-1 Infection Correlates With Immune Activation and Disease Progression
| Autor: | Julian Schulze zur Wiesch, Olaf Degen, Jan van Lunzen, Patrick Dierks, Sebastian Lunemann, Raluca Wroblewski, Ansgar W. Lohse, Anja Hüfner, Marcus Altfeld, Sandra Hertling, Johanna M. Eberhard, Stefan Schmiedel, Gloria Martrus |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell HIV Infections Lymphocyte Activation Polymerase Chain Reaction Peripheral blood mononuclear cell Pathogenesis 03 medical and health sciences Antigen Antigens CD medicine Humans Pharmacology (medical) biology business.industry Apyrase Viral Load Aryl hydrocarbon receptor CD56 Antigen Killer Cells Natural Interleukin 10 030104 developmental biology Infectious Diseases medicine.anatomical_structure Immunology Disease Progression HIV-1 biology.protein business Viral load CD8 |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 74:467-472 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0000000000001266 |
| Popis: | The expression pattern of the ectonucleotidases CD39 and CD73 on natural killer (NK) cells was examined in peripheral blood mononuclear cell of 61 HIV-1-infected patients. Increased frequencies of CD39CD56 NK cells were detectable in untreated HIV patients, which was associated with high viral load, low CD4 T-cell count, and CD8 T-cell activation. Additionally, levels of CD39 on NK cells were inducible by in vitro stimulation of NK cells, correlating with aryl hydrocarbon receptor and interleukin 10 expression. Here, we provide the first evidence of increased CD39CD56 NK cell frequencies during HIV infection, which might have consequences for NK cell function and HIV pathogenesis. |
| Databáze: | OpenAIRE |
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