The PTHrP Functional Domain Is at the Gates of Endochondral Bones
| Autor: | Xuesong Chen, Carolyn M. Macica, Arthur E. Broadus |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cartilage
Articular musculoskeletal diseases medicine.medical_specialty Biology General Biochemistry Genetics and Molecular Biology Chondrocyte Mice History and Philosophy of Science Internal medicine Synovial joint Bone cell medicine Animals Mechanotransduction Endochondral ossification Periosteum Bone Development General Neuroscience Cartilage Parathyroid Hormone-Related Protein musculoskeletal system Enthesis Cell biology medicine.anatomical_structure Endocrinology Lac Operon hormones hormone substitutes and hormone antagonists |
| Zdroj: | Annals of the New York Academy of Sciences. 1116:65-81 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1402.061 |
| Popis: | PTHrP gene-expression products are generally of very low abundance. The PTHrP-lacZ knockin mouse is a useful tool in this regard, identifying PTHrP expression in previously unrecognized sites and serving to score this expression in gene-regulation experiments. These sites include the periosteum and ligament/tendon insertion sites at the surface of endochondral bones, in which PTHrP appears to regulate subjacent bone cell populations. As mesenchymal condensations chondrify, PTHrP/lacZ is also expressed in epiphyseal cartilage (the chondroepiphysis), and this structure contributes PTHrP-expressing chondrocyte populations to both articular cartilage and growth-plate cartilage when these structures take shape postnatally. The Indian hedgehog-PTHrP axis is fully deployed in both of these locations and in articular cartilage appears to protect the joint space from invasion by mineralizing cells. In most of these sites PTHrP is mechanically regulated. |
| Databáze: | OpenAIRE |
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