Hippocampal Function in Healthy Carriers of theCLUAlzheimer's Disease Risk Variant
| Autor: | Markus M. Nöthen, Manuel Mattheisen, Marcella Rietschel, Stephanie H. Witt, Knut Schnell, Sven Cichon, Susanne Erk, Carola Opitz von Boberfeld, Thomas W. Mühleisen, Andreas Meyer-Lindenberg, Christine Esslinger, Henrik Walter, Peter Kirsch |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Genotype Imaging genetics Prefrontal Cortex Hippocampus Disease Neuropsychological Tests Polymorphism Single Nucleotide Young Adult ddc:590 Memory blood supply [Hippocampus] CLU protein human Image Processing Computer-Assisted Humans Genetic Predisposition to Disease In patient Prefrontal cortex physiology [Memory] Brain Mapping Mechanism (biology) General Neuroscience Hippocampal function Middle Aged Magnetic Resonance Imaging Oxygen Clusterin blood [Oxygen] physiopathology [Hippocampus] genetics [Polymorphism Single Nucleotide] Disease risk Female Brief Communications Psychology Neuroscience genetics [Clusterin] Genome-Wide Association Study |
| Zdroj: | The journal of neuroscience 31, 18180-18184 (2011). doi:10.1523/JNEUROSCI.4960-11.2011 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.4960-11.2011 |
| Popis: | Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered atCLU(rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection. |
| Databáze: | OpenAIRE |
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