Metabolic Effects of R-Phenylisopropyladenosine during Reversible Forebrain Ischemia Studied by in vivo 31P Nuclear Magnetic Resonance Spectroscopy
| Autor: | P. Meric, J. Seylaz, J. L. Corrèze, P. Roucher, Jean-Marc Lhoste, Joël Mispelter, B. Tiffon |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Agonist medicine.medical_specialty Magnetic Resonance Spectroscopy Phosphocreatine medicine.drug_class Ischemia Phosphates chemistry.chemical_compound Adenosine A1 receptor Adenosine Triphosphate In vivo Internal medicine medicine Animals Brain Electroencephalography Rats Inbred Strains Nuclear magnetic resonance spectroscopy Hydrogen-Ion Concentration medicine.disease Adenosine Rats Endocrinology Neurology chemistry Ischemic Attack Transient Phenylisopropyladenosine Neurology (clinical) Cardiology and Cardiovascular Medicine Nucleoside medicine.drug |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 11:453-458 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1038/jcbfm.1991.87 |
| Popis: | The metabolic effects of R-phenylisopropyladenosine ( R-PIA), an agonist of adenosine A, receptors, were studied by in vivo 31P NMR spectroscopy before, during, and after 30 min of reversible forebrain ischemia in the rat. R-PIA had no effect on cerebral metabolism before ischemia. During a 30-min ischemia, R-PIA reduced the decrease in phosphocreatine (43 ± 11% of the control level at the end of ischemia vs. 27 ± 9% in the reference group) and ATP (58 ± 12% vs. 40 ± 23%) and the increase in inorganic phosphate (672 ± 210% vs. 905 ± 229%). The intracellular acidosis elicited by ischemia was also less in the treated group (pH of 6.40 ± 0.10 vs. 6.30 ± 0.10). Recirculation was associated with a faster recovery of PCr, ATP, Pi, and pHi to control levels in the treated group than in the reference group. It is concluded that adenosine protects against ischemic injury by mechanisms that include metabolic protection. |
| Databáze: | OpenAIRE |
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