Glycogenolysis in the Rat Isolated Perfused Liver as a Measure of Chemically Induced Liver Toxicity
| Autor: | Kiyoshi Sakai, Yukiko Saitoh, Chie Ikawa, Toshiaki Nishihata |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Glycogenolysis Chemical compound Pharmaceutical Science Alcohol In Vitro Techniques chemistry.chemical_compound Internal medicine medicine Animals Sulfhydryl Compounds Sodium salicylate Pharmacology chemistry.chemical_classification Liver cell Maleates Rats Inbred Strains Salicylates In vitro Liver Glycogen Rats Perfusion Glucose Endocrinology Liver chemistry Toxicity Thiol Dinitrophenols |
| Zdroj: | Journal of Pharmacy and Pharmacology. 40:333-336 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1988.tb05262.x |
| Popis: | The relationship between chemically induced glycogenolysis and decreased thiol content in the rat isolated, perfused liver has been examined. Chemicals such as 2,4-dinitrophenol (DNP), diethyl maleate, alchohols and anti-inflammatory agents (except for sodium salicylate) accelerated glycogenolysis. Protein thiol loss correlated well with a marked increased rate of glucose release. Non-protein thiol loss, without significant loss of protein thiol, caused by a slight increase in the rate of glycogenolysis compared with controls. Since it has been reported that protein thiol loss rather than non-protein thiol loss is correlated to liver cell injury, a marked glucose release from the perfused liver may be a convenient measure of hepatic toxicity for a variety of chemicals. |
| Databáze: | OpenAIRE |
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