Ultrastructural immunohistochemical study of L-type amino acid transporter 1–4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma
| Autor: | Masahiro Ikegami, Eisuke Kume, Yoshikatsu Kanai, Norio Kansaku, Hitoyuki Takahashi, Michael F. Wempe, Shin Wakui, Hitoshi Endou, Tomoko Mutou |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Fusion Regulatory Protein 1 Heavy Chain Angiogenesis Large Neutral Amino Acid-Transporter 1 Extracellular matrix 03 medical and health sciences 0302 clinical medicine Carcinoma medicine Animals Rats Wistar Instrumentation Rat Bladder chemistry.chemical_classification medicine.disease Immunohistochemistry Molecular biology N butyl n 4 hydroxybutyl nitrosamine Rats Amino acid Microscopy Electron 030104 developmental biology Urinary Bladder Neoplasms chemistry 030220 oncology & carcinogenesis Microvessels Ultrastructure Butylhydroxybutylnitrosamine |
| Zdroj: | Journal of Electron Microscopy. 66:198-203 |
| ISSN: | 1477-9986 0022-0744 |
| DOI: | 10.1093/jmicro/dfx008 |
| Popis: | Angiogenesis is essential for tumor growth, and an enhanced vasculature supplying nutrients and oxygen might reflect malignant potential. L-type amino acid transporter 1 (LAT1/4F2hc) comprises a major nutrient transport system responsible for the Na+-independent transport of large neutral amino acids. Seventy five to seventy eight percent N-butyl-N-(4-hydroxybutyl) nitrosamine-induced rat bladder carcinoma cells showed high LAT1/4F2hc expression. While the intracarcinoma microvasculatures of fenestrated endothelial cells highly expressing LAT1/4F2hc might progressively transport essential amino acids from the microvasculatures to the extracellular matrix, non-fenestrated endothelial cells and pericytes did not. The present study revealed that the tumor angiogenesis is one of target anti-L-type amino acid transporter 1 drug. |
| Databáze: | OpenAIRE |
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