Vaccination Against Porcine Circovirus-2 Reduces Severity of Tuberculosis in Wild Boar
| Autor: | Emmanuel Serrano, Luis Gómez, Rocío Iglesias, David Risco, Javier Hermoso de Mendoza, Waldo L. García-Jiménez, Remigio Martínez, Rosario Cerrato, María Bravo, Pedro Fernández-Llario, Pilar Gonçalves, Javier Galapero, J. M. Cuesta, Almudena Torres |
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| Rok vydání: | 2018 |
| Předmět: |
Circovirus
0301 basic medicine Microbiological culture Tuberculosis Swine 040301 veterinary sciences animal diseases Health Toxicology and Mutagenesis Sus scrofa Animals Wild Severity of Illness Index 0403 veterinary science 03 medical and health sciences Wild boar biology.animal Epidemiologia veterinària medicine Animals Circoviridae Infections Swine Diseases Ecology biology Coinfection business.industry Vaccination virus diseases Viral Vaccines 04 agricultural and veterinary sciences biology.organism_classification medicine.disease Porcine circovirus Senglars 030104 developmental biology Porcs Spain Animal ecology Immunology Malalties Vacunació d'animals business |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| Popis: | Dr. D. Risco was supported by a Torres Quevedo Grant of the Ministerio de Economía y Competitividad of Spain (PTQ14-06663 and RYC-2016-21120) and by the postdoctoral programme of the Gobierno de Extremadura (Ref PO14024). E. Serrano was funded by the Spanish Ministerio de Economia y Competitividad (MINECO) through a Ramon y Cajal agreement (RYC-2016-21120). Tuberculosis (TB) in wild boar (Sus scrofa) may be affected by coinfections with other pathogens, such as porcine circovirus type 2 (PCV2). Therefore, sanitary measures focused on controlling PCV2 could be useful in reducing the impact of TB in this wild suid. The aim of this study was to explore whether vaccination against PCV2 targeting young animals affects TB prevalence and TB severity in wild boar. The study was conducted on a game estate in mid-western Spain. Seventy animals of ages ranging from 4 to 8 months were captured, individually identified, vaccinated against PCV2 and released, forming a vaccinated group. Not-captured animals cohabiting with the vaccinated wild boar constituted the control group. Animals from both groups were hunted between 2013 and 2016 and a TB diagnosis based on pathological assessment and microbiological culture was made in all of them. The effect of PCV2 vaccination on TB prevalence and severity was explored using generalized lineal models. Whereas TB prevalence was similar in vaccinated and control groups (54.55 vs. 57.78%), vaccinated animals showed less probabilities to develop generalized TB lesions. Furthermore, mean TB severity score was significantly lower in vaccinated animals (1.55 vs. 2.42) suggesting a positive effect of PCV2 vaccination. |
| Databáze: | OpenAIRE |
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