Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil
| Autor: | Costa Ir, K.K.V.O. Moura, A.B. Frare, B.M. Bordin, Ribeiro Júnior Cl, R.C.P.C. Silva, Souza, Silva Ct |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Genotype Endometriosis law.invention Andrology chemistry.chemical_compound Alu Elements Risk Factors law Progesterone receptor Genetics medicine Humans Genetic Predisposition to Disease In patient Molecular Biology Polymerase chain reaction Polymorphism Genetic business.industry General Medicine Progesterone Receptor Gene Middle Aged medicine.disease chemistry Female Receptors Progesterone business Ethidium bromide Brazil Genome-Wide Association Study |
| Zdroj: | Genetics and Molecular Research. 10:1364-1370 |
| ISSN: | 1676-5680 |
| DOI: | 10.4238/vol10-3gmr913 |
| Popis: | We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis. |
| Databáze: | OpenAIRE |
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