Impairment of Sexual Behaviour in Female Rats with Impaired Glucose Tolerance Due to Streptozotocin Treatment of Their Maternal Grandmothers
| Autor: | Andreas Plagemann, Renate Tönjes, Günter Dörner |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Carbohydrate metabolism Streptozocin Diabetes Mellitus Experimental Prediabetic State Impaired glucose tolerance Sexual Behavior Animal Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Animals Prediabetes business.industry Rats Inbred Strains General Medicine medicine.disease Streptozotocin Hypoplasia Rats Glucose Hypothalamus Decreased glucose tolerance Female business medicine.drug |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 91:369-372 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1210772 |
| Popis: | A decreased receptive sexual behaviour was found in female F2-offspring of Streptozotocin-treated maternal grandmothers. These F2-offspring are characterized by decreased glucose tolerance and increased diabetes susceptibility, their metabolic situation being comparable to that of Type II prediabetes. The observed phenomena were associated with permanent hypoplasia of the hypothalamic ventromedial nucleus (HVN). It is hypothesized that there could be a causal relationship between these morphological changes in the HVN and impaired sexual behaviour in female prediabetic rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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