The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients
| Autor: | Renato Malta, R. D'agostino, G. Reina, S. Mansueto, Giustina Vitale, G. Gambino, C. Mocciaro, Maria Dieli, Enrico Cillari |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Interleukin 2
Immunology Leishmania donovani Biology Peripheral blood mononuclear cell Interferon-gamma Antigen medicine Animals Humans Immunology and Allergy IL-2 receptor Sicily Phytohaemagglutinin Receptors Interleukin-2 Leishmaniasis medicine.disease biology.organism_classification Visceral leishmaniasis Solubility Leukocytes Mononuclear biology.protein Interleukin-2 Leishmaniasis Visceral Research Article medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.1992.tb07932.x |
| Popis: | SUMMARY Sera from nine Sicilian patients with confirmed visceral leishmaniasis (Leishmania donovani infantum; VL), at the moment of the diagnosis, during the course of the disease and after clinical recovery, were analysed for the concentration of soluble IL-2 receptor (sIL-2R). The results show that sIL-2R is a marker of disease activity, since it is in high concentration at the beginning of infection and returns to the normal range following successful chemotherapy. At the same time of serum analysis for sIL-2R, peripheral blood mononuclear cells (PBMC) of VL patients were stimulated with phytohaemagglutinin (PHA) or antigen and supernatant tested for IL-2 and interferon-gamma (IFN-γ) production. Data demonstrate that there is an inverse relation between concentration of IL-2 and IFN-γ in the supernatants and sIL-2R secretion in the sera. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|