A real-life prospective health economic study of elective single embryo transfer versus two-embryo transfer in first IVF/ICSI cycles
| Autor: | M Vercruyssen, Lieven Annemans, J Vander Elst, K Mangelschots, Marc Dhont, Monique Elseviers, P. De Sutter, Diane De Neubourg, P Pauwels, P Kok, E Van Royen, Jan Gerris |
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| Přispěvatelé: | Gyneacology-Urology, Department of Embryology and Genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Pregnancy test
Postnatal Care medicine.medical_specialty single versus two-embryo transfer Pregnancy Rate medicine.medical_treatment Twins Single Embryo Transfer Fertilization in Vitro single embryo transfer Pregnancy assisted reproductive technology medicine Humans Prospective Studies Sperm Injections Intracytoplasmic health economic analysis Birth Rate Biology Gynecology Assisted reproductive technology business.industry Obstetrics Rehabilitation Infant Newborn Obstetrics and Gynecology Health Care Costs medicine.disease Delivery Obstetric Embryo Transfer Embryo transfer Hospitalization Pregnancy rate Reproductive Medicine Premature birth Female Human medicine Pregnancy Multiple Live birth business Infant Premature |
| Zdroj: | Human reproduction |
| ISSN: | 0268-1161 |
| Popis: | BACKGROUND: We analysed the difference in maternal, neonatal and total costs after single (SET) versus double day 3 embryo transfer (DET). METHODS: We performed a two-centre prospective study of women in their first IVF/ICSI cycle choosing between SET or DET. Infertility treatment data were gathered from a database; maternal and neonatal outcome data from a case report form (CRF); health economic data from medical acts registered in the CRF for the outpatient part and from hospital bills. SET was performed in 206/367 (56.1%) and DET in 161/367 (43.9%) women. RESULTS: In all, 367 transfers yielded 186 positive pregnancy tests, 148 ongoing pregnancies and 136 live deliveries (50.7, 40.3 and 37.1% per embryo transfer) of which 15 (11.0%) were twins. Live birth rate was 37.4% for SET, 36.6% for DET. Intention-to-treat analysis showed differences for: duration of pregnancy (SET: 39.0 ± 1.4 versus DET: 38.3 ± 2.2 weeks; P = 0.055), percentage prematurity (8.5 versus 23.8%; P = 0.033), percentage of neonates hospitalized (5.7 versus 17.9%; P = 0.121) and duration of neonatal hospitalization (6.3 ± 2.2 versus 10.3 ± 10.1 days; P = 0.01). Total cost after DET was higher (SET: 4700 ± 3239 versus DET: 8613 ± 10 105; P = 0.105), due to significantly higher neonatal costs (451 ± 957 versus 3453 ± 8154; P < 0.001) and not to differences in maternal costs (4250 ± 2882 versus 5160 ± 4106; P = 0.152). CONCLUSIONS: This prospective health economic study shows that transfer of a single top quality embryo is equally effective as, but substantially cheaper than, double embryo transfer in women |
| Databáze: | OpenAIRE |
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