Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study
| Autor: | Bas J. Zwaan, Jacob J.E. Koopman, P. Eline Slagboom, Rudi G. J. Westendorp, David van Bodegom, Stefan Böhringer, Ulrika K. Eriksson, Peter de Knijff, Juventus B. Ziem, Hernando Sanchez-Faddeev, Jeroen Pijpe |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine life history Aging Survival Ghana Gene 0302 clinical medicine 030212 general & internal medicine Young adult media_common Genetics fertility Middle Aged PE&RC Survival Rate Phenotype Female Laboratory of Genetics Research Paper Human Adult Genotype Evolution media_common.quotation_subject Longevity SNP Single-nucleotide polymorphism Fertility Biology Population stratification Laboratorium voor Erfelijkheidsleer Polymorphism Single Nucleotide survival Life history theory Young Adult 03 medical and health sciences Genetic variation evolution Humans human Life history gene Survival rate Genetic Association Studies Aged Genetic heterogeneity aging Infant Newborn Genetic Variation Cell Biology 030104 developmental biology Africa Demography |
| Zdroj: | Aging, 8(7), 1364-1383 Aging 8 (2016) 7 Aging Aging (Albany NY) Koopman, J J E, Pijpe, J, Böhringer, S, van Bodegom, D, Eriksson, U K, Sanchez-Faddeev, H, Ziem, J B, Zwaan, B, Slagboom, P E, de Knijff, P & Westendorp, R G J 2016, ' Genetic variants determining survival and fertility in an adverse African environment : a population-based large-scale candidate gene association study ', Aging, vol. 8, no. 7, pp. 1364-1383 . https://doi.org/10.18632/aging.100986 |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.100986 |
| Popis: | Human survival probability and fertility decline strongly with age. These life history traits have been shaped by evolution. However, research has failed to uncover a consistent genetic determination of variation in survival and fertility. As an explanation, such genetic determinants have been selected in adverse environments, in which humans have lived during most of their history, but are almost exclusively studied in populations in modern affluent environments. Here, we present a large-scale candidate gene association study in a rural African population living in an adverse environment. In 4387 individuals, we studied 4052 SNPs in 148 genes that have previously been identified as possible determinants of survival or fertility in animals or humans. We studied their associations with survival comparing newborns, middle-age adults, and old individuals. In women, we assessed their associations with reported and observed numbers of children. We found no statistically significant associations of these SNPs with survival between the three age groups nor with women's reported and observed fertility. Population stratification was unlikely to explain these results. Apart from a lack of power, we hypothesise that genetic heterogeneity of complex phenotypes and gene-environment interactions prevent the identification of genetic variants explaining variation in survival and fertility in humans. |
| Databáze: | OpenAIRE |
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