Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures
| Autor: | Toshiaki Kume, Takaaki Matsuo, Yasuhiko Izumi, Yuki Takada-Takatori, Hideyuki Sawada, Akinori Akaike |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Time Factors
Cell Survival Dopamine Aripiprazole Glutamic Acid Pharmacology Quinolones Partial agonist Glutamate cytotoxicity Drug Administration Schedule Piperazines chemistry.chemical_compound Dopamine Uptake Inhibitors Mesencephalon Dopamine receptor D2 medicine Animals Drug Interactions Neurotransmitter Cells Cultured Chromatography High Pressure Liquid Neuroprotective effec Neurons Dose-Response Relationship Drug Chemistry General Neuroscience Dopaminergic Glutamate receptor Embryo Mammalian Rats Neuroprotective Agents Sulpiride Intracellular dopamine content medicine.drug |
| Zdroj: | Neuroscience letters. 481(2):78-81 |
| ISSN: | 0304-3940 |
| Popis: | Aripiprazole, a dopamine D2 receptor partial agonist, is used to treat schizophrenia. Although aripiprazole has been reported to protect non-dopaminergic neurons, its effect on dopaminergic neurons has yet to be investigated. In the present study, we examined whether aripiprazole protected dopaminergic neurons against glutamate-induced cytotoxicity in rat mesencephalic cultures. Pretreatment with aripiprazole protected dopaminergic neurons in a concentration-dependent manner. The neuroprotective effect was not attenuated by sulpiride, a dopamine D2 receptor antagonist, suggesting that the effect is independent of dopamine D2 receptors. Aripiprazole reduced intracellular dopamine content in a concentration-dependent manner. In addition, its neuroprotective effect was partially inhibited when dopamine was added. These results suggest that aripiprazole protects dopaminergic neurons against glutamate cytotoxicity partly by reducing intracellular dopamine content. |
| Databáze: | OpenAIRE |
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