Flat Epithelial Atypia in Breast Core Needle Biopsies With Radiologic-Pathologic Concordance
| Autor: | Monica Morrow, Edi Brogi, Elena D. Salagean, Anne Grabenstetter, Sandra B. Brennan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Conservative Treatment Risk Assessment Article 030218 nuclear medicine & medical imaging Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Biopsy Site Biopsy Atypia medicine Carcinoma Humans Breast Nuclear atypia Mastectomy Aged Retrospective Studies medicine.diagnostic_test business.industry Carcinoma Ductal Breast Middle Aged Ductal carcinoma medicine.disease Magnetic Resonance Imaging Carcinoma Lobular Carcinoma Intraductal Noninfiltrating 030220 oncology & carcinogenesis Female Surgery Biopsy Large-Core Needle Ultrasonography Mammary Radiology Anatomy business Precancerous Conditions Follow-Up Studies Mammography Lobular Neoplasia |
| Zdroj: | Am J Surg Pathol |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000001385 |
| Popis: | Flat epithelial atypia (FEA) is an alteration of terminal duct lobular units by a proliferation of ductal epithelium with low-grade atypia. No consensus exists on whether the diagnosis of FEA in core needle biopsy (CNB) requires excision (EXC). We retrospectively identified all in-house CNBs obtained between January 2012 and July 2018 with FEA. We reviewed all CNB slides and assessed radiologic-pathologic concordance. An upgrade was defined as invasive carcinoma (IC) and/or ductal carcinoma in situ in the EXC. The EXC slides of all upgraded cases were rereviewed. Out of ∼15,700 consecutive CNBs in the study period, 106 CNBs from 106 patients yielded FEA alone or with classic lobular neoplasia (LN). We excluded 52 CNBs (40 patients with prior/concurrent carcinoma and 12 without EXC). After rereview, we reclassified 14 cases (2 marked nuclear atypia, 10 focal atypical ductal hyperplasia, 2 benign). The final FEA study cohort consisted of 40 CNBs from 40 women. The CNB targeted mammographic calcifications in 36 (90%) cases, magnetic resonance imaging nonmass enhancement in 3 (8%), and 1 (2%) sonographic mass. All CNBs were deemed radiologic-pathologic concordant. FEA was present alone in 34 CNBs and with LN in 6. EXC yielded 2 low-grade IC, each spanning |
| Databáze: | OpenAIRE |
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