Palladium-Catalyzed Template Directed C-5 Selective Olefination of Thiazoles
| Autor: | Tapas Pal, Tapas Kumar Achar, Jyoti Prasad Biswas, Sandip Porey, Siddhartha Maiti, Kankanala Ramakrishna, Debabrata Maiti |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Intermolecular force chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Metal chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Chelation Bifunctional Thiazole Selectivity Palladium |
| Zdroj: | The Journal of Organic Chemistry. 84:8315-8321 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/acs.joc.9b01074 |
| Popis: | An efficient method has been developed to afford highly C-5 selective olefination of thiazole derivatives utilizing a bifunctional template in an intermolecular fashion. Coordinative interaction between the substrates and the metal chelated template backbone plays a crucial role in high C-5 selectivity. Excellent selectivity for the C-5 position was observed while mono substituted (2- or 4-) or even more challenging unsubstituted thiazoles were employed. |
| Databáze: | OpenAIRE |
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