Mean Platelet Volume and Platelet Function Analysis in Acromegalic Patients Before and after Treatment
| Autor: | İsmail Karademirci, Mustafa Demirpence, Ayfer Colak, Burak Toprak, Hamiyet Yilmaz Yasar, Baris Akinci, Serkan Yener |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism Fibrinogen medicine.disease Gastroenterology Function analysis Endocrinology Epinephrine Internal medicine Acromegaly Medicine Platelet Platelet activation Mean platelet volume business General Endocrinology After treatment medicine.drug |
| Zdroj: | Acta Endocrinologica (Bucharest). 12:401-406 |
| ISSN: | 1843-066X 1841-0987 |
| DOI: | 10.4183/aeb.2016.401 |
| Popis: | Objective Mean platelet volume (MPV) and platelet function analysis have been studied before in acromegaly, but the effect of treatment on both parameters has not been evaluated. We aimed to investigate MPV and platelet function analysis in acromegalic patients after six-months of treatment. Methods Forty patients with active acromegaly and 36 healthy subjects were included in the study. Plasma glucose and lipids, fibrinogen, GH, IGF-1 levels, MPV and platelet function analysis were measured. All patients with acromegaly were re-evaluated six months after treatment. Results Fasting blood glucose (FBG), GH, IGF-1, fibrinogen levels and MPV values were significantly higher in acromegalic group compared with the control. Platelet function was enhanced significantly (pcol-ADP: 0.002, pcolepinephrine: 0.002). After 6 months of treatment FBG, serum GH, IGF-1, fibrinogen and MPV decreased and collagen/ADP- and collagen/epinephrine-closure times (CT) were increased. Acromegalic patients that were in remission with long-acting SSA after surgery had significantly higher fibrinogen levels and MPV and decreased collagen/epinephrine-CT with respect to the controls (pfibrinogen: 0.001, pMPV: 0.026, pcol-epinephrine: 0.037). Conclusion Acromegaly was associated with increased MPV and enhanced platelet activity. Although growth hormone hypersecretion was controlled by surgery and medical treatment, these parameters did not improve - indicating a still increased risk for cardiovascular events. |
| Databáze: | OpenAIRE |
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