Micronutrient concentrations and subclinical atherosclerosis in adults with HIV
| Autor: | Joseph F. Polak, Clara Y. Jones, Alice M. Tang, Margo N. Woods, E Liana Falcone, Christine Wanke, Alexandra Mangili |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Cross-sectional study Lipoproteins medicine.medical_treatment Population Medicine (miscellaneous) HIV Infections Gastroenterology Selenium chemistry.chemical_compound Antiretroviral Therapy Highly Active Internal medicine medicine Humans Vitamin E Longitudinal Studies Micronutrients cardiovascular diseases Vitamin A education education.field_of_study Nutrition and Dietetics business.industry Retinol Middle Aged Viral Load Atherosclerosis Cardiovascular disease risk Micronutrient Coronary Calcium Score Zinc Carotid Arteries Cross-Sectional Studies chemistry Immunology Cohort Disease Progression cardiovascular system Female Tunica Intima Tunica Media business |
| Zdroj: | The American Journal of Clinical Nutrition. 91:1213-1219 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.2009.28816 |
| Popis: | Extremes in micronutrient intakes are common in HIV-infected patients in developed countries and may affect the progression of atherosclerosis in this population.We completed a cross-sectional study examining the association between serum micronutrient concentrations and surrogate markers of atherosclerosis in a cohort of HIV-infected adults.We measured serum selenium, zinc, vitamin A, and vitamin E concentrations as well as carotid intima-media thickness (c-IMT) and coronary artery calcium (CAC) in 298 Nutrition for Healthy Living participants. We assessed cardiovascular disease risk factors, c-IMT, and CAC for each micronutrient tertile by using a chi-square test for binary variables and analysis of variance for continuous variables. We performed multivariate regression of c-IMT and CAC with each micronutrient with adjustment for HIV-related and cardiovascular disease risk factors.In the multivariate analysis, the highest tertile of serum vitamin E concentration was associated with higher common and internal c-IMT and CAC scores (P0.05 for c-IMT and CAC). Participants with higher vitamin E concentrations were more likely to have detectable CAC (50% compared with 44% compared with 67% for tertiles 1, 2, and 3, respectively; P = 0.004) and common c-IMT0.8 mm (5% compared with 4% compared with 17% for tertiles 1, 2, and 3, respectively; P = 0.002). Other than vitamin E, micronutrients had no association with markers of atherosclerosis.Our study showed that elevated serum vitamin E concentrations are associated with abnormal markers of atherosclerosis and may increase the risk of cardiovascular complications in HIV-infected adults. |
| Databáze: | OpenAIRE |
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