Additional file 1 of Ultra-sensitive RDT performance and antigen dynamics in a high-transmission Plasmodium falciparum setting in Mali

Autor: Reichert, Emily N., Hume, Jen C. C., Issaka Sagara, Healy, Sara A., Mahamadoun H. Assadou, Merepen A. Guindo, Barney, Rebecca, Rashid, Andy, Ihn Kyung Yang, Golden, Allison, Domingo, Gonzalo J., Duffy, Patrick E., Slater, Hannah C.
Rok vydání: 2020
Předmět:
DOI: 10.6084/m9.figshare.12916072
Popis: Additional file 1: Figure S1. Scatterplot showing correlation between parasite count by microscopy and HRP2 concentration quantified by Q-Plex ELISA (R2 = 0.29) for all samples P. falciparum positive by microscopy (> 0 parasites/µL). Abbreviations: ELISA, enzyme-linked immunosorbent assay; HRP2, histidine rich protein 2; pLDH, Plasmodium lactate dehydrogenase. Figure S2. Scatterplot showing correlation between parasite count by microscopy and pLDH concentration quantified by Q-Plex ELISA (R2 = 0.61) for all samples P. falciparum positive by microscopy (> 0 parasites/µL). Table S1. Antigen ratios by direct skin feed (DSF) infectivity status. Geometric means for the two antigens of interest, HRP2 and pLDH, along with the geometric mean HRP2:pLDH ratio for study participants that were DSF-positive (n = 11) or DSF-negative (n = 603), grouped by microscopy result. Individuals positive by DSF had a significantly lower HRP2:pLDH ratio (p = 0.02) on average in reference to DSF and microscopy negative individuals. Abbreviations: geo, geometric; HRP2, histidine rich protein 2; pLDH, Plasmodium lactate dehydrogenase; SD, standard deviation.
Databáze: OpenAIRE