Bisphosphonate-induced orbital inflammation in a patient on chronic immunosuppressive therapy

Autor: Radwan Ajlan, Yong Kam, Mary Champion, Thomas J. Whittaker, Isabella Herrera
Rok vydání: 2019
Předmět:
medicine.medical_specialty
Side effect
medicine.medical_treatment
Administration
Oral
Case Report
Chronic inflammatory demyelinating polyneuropathy
Inflammation
Zoledronic Acid
03 medical and health sciences
0302 clinical medicine
lcsh:Ophthalmology
Prednisone
Humans
Lupus Erythematosus
Systemic
Medicine
Infusions
Intravenous
Glucocorticoids
Osteoporosis
Postmenopausal
Past medical history
Bone Density Conservation Agents
Orbital pseudotumor
business.industry
Immunosuppression
General Medicine
Middle Aged
Bisphosphonate
medicine.disease
Magnetic Resonance Imaging
Dermatology
eye diseases
Ophthalmology
Sjogren's Syndrome
Zoledronic acid
Polyradiculoneuropathy
Chronic Inflammatory Demyelinating
lcsh:RE1-994
Cyclosporine
030221 ophthalmology & optometry
Bisphosphonate therapy
Female
Orbital inflammation
medicine.symptom
business
Immunosuppressive Agents
030217 neurology & neurosurgery
medicine.drug
Zdroj: BMC Ophthalmology, Vol 19, Iss 1, Pp 1-3 (2019)
BMC Ophthalmology
ISSN: 1471-2415
DOI: 10.1186/s12886-019-1063-8
Popis: Background To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy. Case presentation A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. She has a past medical history of chronic inflammatory demyelinating polyneuropathy, Sjogren’s syndrome, and systemic lupus erythematosus that have been controlled with immunosuppressive therapy for three years. Clinical ophthalmic exam and MRI studies were significant for right orbital inflammation. The patient was started on oral prednisone with rapid resolution of symptoms. Conclusions This is the first case report of a patient receiving chronic immunosuppressive therapy to develop orbital inflammation after Zoledronic acid infusion. In addition, it demonstrates that corticosteroids can be an effective first line therapy in treating orbital inflammation in similar patients. Physicians should be aware of this rare but serious potential side effect of bisphosphonates, and have bisphosphonate-related orbital inflammation on their differential for proper initiation of treatment.
Databáze: OpenAIRE
Externí odkaz: