Distribution and excretion of C14-labeled ABBOTT-16612 in experimental animals
| Autor: | Arthur Alter, Earl V. Cardinal, Ann Dalziel, Preston M. Bauman, Jonathan P. Miller |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Male
medicine.medical_specialty Urine Kidney Toxicology Piperazines Excretion Feces Mice chemistry.chemical_compound Dogs Species Specificity Internal medicine medicine Animals Distribution (pharmacology) Lung Pharmacology Carbon Isotopes Gastrointestinal tract biology Myocardium Kidney metabolism Haplorhini biology.organism_classification Rats Piperazine Endocrinology Liver chemistry Female Digestive System Spleen |
| Zdroj: | Toxicology and Applied Pharmacology. 8:295-305 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/s0041-008x(66)80016-9 |
| Popis: | Summary The tissue distribution and excretion of C 14 -labeled ABBOTT-16612, a disubstituted piperazine with schistosomicidal activity, have been studied in the rat, mouse, dog, and monkey. The results of the rate of excretion and tissue distribution studies of C 14 -labeled ABBOTT-16612 or its metabolites do not explain the greater susceptibility of the dog, as opposed to the monkey, to the toxic effects of the drug. The highest concentration of C 14 in all species studied was found in the liver and bile of monkeys and dogs. Only 2–4% of the dose was excreted in the urine over a 4-day period. The gastrointestinal tract and its contents contained a high concentration of C 14 . The estimated biological half-life of C 14 -labeled ABBOTT-16612 after a single oral dose is approximately 5 hours in the mouse, 19 hours in the dog, and 53 hours in the monkey. The serum concentration curves in dogs and monkeys were biphasic, with a short-lived component with a half-life of 3–4 hours, and a longer-lived component with a half-life of 52–92 hours. |
| Databáze: | OpenAIRE |
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