Comparative effectiveness of i-SCAN™ and high-definition white light characterizing small colonic polyps
| Autor: | Ziad F. Gellad, Johanna L Chan, Andrew I Wolf, Michael Feiler, Li Lin, Diana M. Cardona |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Comparative Effectiveness Research Light Brief Article Biopsy Comparative effectiveness research Colonoscopy Colonic Polyps Pilot Projects Predictive Value of Tests otorhinolaryngologic diseases medicine White light North Carolina Humans Prospective Studies neoplasms Aged Chi-Square Distribution medicine.diagnostic_test business.industry Gastroenterology pathological conditions signs and symptoms General Medicine Middle Aged medicine.disease digestive system diseases surgical procedures operative Chromogenic Compounds Predictive value of tests Colonic Neoplasms Linear Models High definition Female Radiology business Chi-squared distribution |
| Zdroj: | World journal of gastroenterology. 18(41) |
| ISSN: | 2219-2840 |
| Popis: | To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.This is a single-center comparative effectiveness pilot study. Polyps (n = 103) from 75 average-risk adult outpatients undergoing screening or surveillance colonoscopy between December 1, 2010 and April 1, 2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center. Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology. We determined diagnostic characteristics of i-SCAN and high-definition white light, including sensitivity, specificity, and accuracy, with regards to identifying adenomatous vs non-adenomatous polyps. Histopathologic diagnosis was the gold standard comparison.One hundred and three small polyps, detected from forty-three patients, were included in the analysis. The average size of the polyps evaluated in the analysis was 3.7 mm (SD 1.3 mm, range 2 mm to 8 mm). Formal histopathology revealed that 54/103 (52.4%) were adenomas, 26/103 (25.2%) were hyperplastic, and 23/103 (22.3%) were other diagnoses include "lymphoid aggregates", "non-specific colitis," and "no pathologic diagnosis." Overall, the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN (71.8%, 95%CI: 62.1%-80.3%) and high-definition white light (71.8%, 95%CI: 62.1%-80.3%). However, the accuracy of each endoscopist differed substantially, where endoscopist A demonstrated 63.0% overall accuracy (95%CI: 50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy (95%CI: 77.9%-99.2%), irrespective of imaging modality. Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study. Though endoscopist A increased accuracy using i-SCAN from 59% (95%CI: 42.1%-74.4%) in the first half to 67.6% (95%CI: 49.5%-82.6%) in the second half, and endoscopist B decreased accuracy using i-SCAN from 100% (95%CI: 80.5%-100.0%) in the first half to 84.6% (95%CI: 54.6%-98.1%) in the second half, neither of these differences were statistically significant.i-SCAN and high-definition white light had similar efficacy predicting polyp histology. Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|