Gypenosides Protected the Neural Stem Cells in the Subventricular Zone of Neonatal Rats that Were Prenatally Exposed to Ethanol

Autor: Fang-Miao Jing, Lun Dong, Zhen-Hua Shang, Hua Xin, Kun-Qi Yang, Qing-Yu Zhang, Wen-Yan Fu, Xiao-Jing Wang, Lin-Lin Li
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Doublecortin Domain Proteins
Cellular differentiation
Cell Count
Hippocampal formation
Nestin
lcsh:Chemistry
Neural Stem Cells
Pregnancy
Lateral Ventricles
lcsh:QH301-705.5
Spectroscopy
reproductive and urinary physiology
Glial fibrillary acidic protein
Neurogenesis
subventricular zone
Cell Differentiation
General Medicine
Neural stem cell
Computer Science Applications
Neuroprotective Agents
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Female
Microtubule-Associated Proteins
gypenosides
medicine.medical_specialty
Subventricular zone
fetal alcohol spectrum disorder
Biology
Neuroprotection
Article
Catalysis
Inorganic Chemistry
Internal medicine
Glial Fibrillary Acidic Protein
medicine
Animals
Rats
Wistar
Physical and Theoretical Chemistry
Cell Shape
Molecular Biology
Ethanol
Plant Extracts
Neuropeptides
Organic Chemistry
Embryo
Mammalian
Gynostemma
Endocrinology
cell proliferation
Animals
Newborn
nervous system
lcsh:Biology (General)
lcsh:QD1-999
Cytoprotection
Immunology
biology.protein
Zdroj: International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 21967-21979 (2014)
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 21967-21979
ISSN: 1422-0067
Popis: Fetal alcohol spectrum disorder (FASD) can cause severe mental retardation in children who are prenatally exposed to ethanol. The effects of prenatal and early postnatal ethanol exposure on adult hippocampal neurogenesis have been investigated
however, the effects of prenatal ethanol exposure on the subventricular zone (SVZ) have not. Gypenosides (GPs) have been reported to have neuroprotective effects in addition to other bioactivities. The effects of GPs on neural stem cells (NSCs) in the FASD model are unknown. Here, we test the effect of prenatal ethanol exposure on the neonatal SVZ, and the protection potential of GPs on NSCs in FASD rats. Our results show that prenatal ethanol exposure can suppress the cell proliferation and differentiation of neural stem cells in the neonatal SVZ and that GPs (400 mg/kg/day) can significantly increase the cell proliferation and differentiation of neural stem cells inhibited by ethanol. Our data indicate that GPs have neuroprotective effects on the NSCs and can enhance the neurogenesis inhibited by ethanol within the SVZ of neonatal rats. These findings provide new evidence for a potential therapy involving GPs for the treatment of FASD.
Databáze: OpenAIRE
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