The effect of subthalamic nucleus - Deep brain stimulation and different stimulation frequencies on cerebral hemodynamics in Parkinson's disease: A transcranial doppler study

Autor: Orkun Koban, Mustafa Turgut Yildizgoren, Atilla Yilmaz, Yurdal Serarslan, Esra Emine Okuyucu, Sadık Ahmet Uyanık, Mustafa Aras, Sukru Oral
Přispěvatelé: Ondokuz Mayıs Üniversitesi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Middle Cerebral Artery
Deep brain stimulation
Parkinson's disease
Ultrasonography
Doppler
Transcranial
medicine.medical_treatment
Blood flow velocity
Deep Brain Stimulation
Hemodynamics
Stimulation
03 medical and health sciences
0302 clinical medicine
Subthalamic Nucleus
Internal medicine
medicine.artery
medicine
Humans
Transcranial doppler ultrasound
Aged
business.industry
Pulsatility index
Parkinson Disease
General Medicine
Blood flow
Middle Aged
medicine.disease
Transcranial Doppler
nervous system diseases
Subthalamic nucleus
surgical procedures
operative
nervous system
030220 oncology & carcinogenesis
Cerebrovascular Circulation
Middle cerebral artery
Cardiology
Surgery
Female
Vascular Resistance
Neurology (clinical)
business
Resistance index
therapeutics
030217 neurology & neurosurgery
Blood Flow Velocity
Popis: WOS: 000534371300023 PubMed: 32200216 Objectives: To investigate the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) and to compare low-frequency versus high-frequency STN-DBS on hemodynamic parameters of the middle cerebral artery between patients with advanced Parkinson's disease and age-sex matched healthy controls. Patients and Methods: Eighteen patients with advanced Parkinson's disease (PD) with bilateral STN-DBS and 18 control subjects underwent Transcranial Doppler Ultrasound (TCDU) were included in the study. The hemodynamic parameters including blood flow velocity (FV), pulsatility index (PI) and, resistance index (RI) of the right middle cerebral artery (MCA) were measured and compared during the phases using TCDU. The first DBS-off, the second low-frequency DBS of 60 Hz, and the third high-frequency DBS of 130 Hz were compared. Results: PD patients had significantly higher MCA-PI values compared with controls (0.99 +/- 0.27 vs. 0.82 +/- 0.14) (p = 0.031). Also, the MCA-PI values were higher in the low-frequency DBS (0.94 +/- 0.14) and high-frequency DBS (0.93 +/- 0.16) than in the controls (0.82 +/- 0.14) (p = 0.022 and p = 0.041, respectively). There were no significant differences of FV and RI values among the DBS-on, DBS-off and, controls. The RI values were higher in the PD patients than in the controls, although these were not statistically significant. Also, PI values of the MCA decrease in different frequencies (60 Hz or 130 Hz). Conclusion: The results of this study showed that MCA-PI values are higher in advanced PD compared with controls. These indices indicate that MCA resistances and impedances are increased in advanced PD. Low- or high-frequency DBS treatment have beneficial effect to reduce high PI in advanced PD patients.
Databáze: OpenAIRE
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