Baseline insulin resistance is a determinant of the small, dense low-density lipoprotein response to diets differing in saturated fat, protein, and carbohydrate contents
| Autor: | Penny M. Kris-Etherton, Michael A. Roussell, Alison M. Hill, Xiuzhi Wu, Rosemary L. Walzem |
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| Přispěvatelé: | Wu, Xiuzhi, Roussell, Michael A, Hill, Alison M, Kris-Etherton, Penny M, Walzem, Rosemary L |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
saturated fat Apolipoprotein B Dietary Approaches To Stop Hypertension Saturated fat Hypercholesterolemia insulin resistance diet response beef consumption Article chemistry.chemical_compound Animal science Insulin resistance Dash medicine Dietary Carbohydrates Humans TX341-641 Nutrition and Dietetics Cross-Over Studies biology Nutrition. Foods and food supply Fatty Acids Carbohydrate Middle Aged medicine.disease Dietary Fats Lipoproteins LDL Red Meat chemistry Low-density lipoprotein Saturated fatty acid biology.protein Female Dietary Proteins Diet Healthy Food Science Lipoprotein |
| Zdroj: | Nutrients, Vol 13, Iss 4328, p 4328 (2021) Nutrients Nutrients; Volume 13; Issue 12; Pages: 4328 |
| Popis: | Individual responses to diet vary but causes other than genetics are poorly understood. This study sought to determine whether baseline values of homeostasis model assessment (HOMA-IR) was related to changes in small, dense low-density lipoprotein (sdLDL, i.e., LDL4, d = 1.044–1.063 g/mL) amounts quantified by isopycnic density profiling, in mildly hypercholesterolemic subjects (n = 27) consuming one of three low saturated fatty acid (SFA) diets: Dietary Approaches to Stop Hypertension (DASH), Beef in an Optimal Lean Diet (BOLD) and BOLD plus extra protein (BOLD+) when compared to a higher-SFA healthy American diet (HAD). The diets were consumed in random order for 5 wk, with 1 wk between diets. BOLD+ reduced fractional abundance (%) LDL4 (p < 0.05) relative to HAD, DASH and BOLD, and reductions in % LDL4 correlated with reductions in triglycerides (p = 0.044), total cholesterol (p = 0.014), LDL cholesterol (p = 0.004) and apolipoprotein B (p < 0.001). Responses to the four diets were similar (~12% decrease in % LDL4, p = 0.890) in the lower (p = 0.013), in which % LDL4 was reduced with BOLD+ (−11%), was unchanged in BOLD and increased with the HAD (8%) and DASH (6%) diets (p < 0.05 for BOLD+ vs. HAD). Individual responses to diet interventions are influenced by presence and degree of insulin resistance as measured by HOMA-IR. |
| Databáze: | OpenAIRE |
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