Correlation between serum levels of vascular endothelial growth factor-C and sentinel lymph node status in early breast cancer

Autor: Francisco Rivas-Ruiz, Gonzalo Callejón, Francisco Medina, Elisabeth Pérez-Ruiz, Antonio Rueda, R. Villatoro, Claudio Maañón, Alexander Rohde, Isabel Rodrigo, Belen Ramos, Irene Zarcos, Maximino Redondo, Diego Perez
Rok vydání: 2015
Předmět:
Zdroj: Tumor Biology. 36:9285-9293
ISSN: 1423-0380
1010-4283
DOI: 10.1007/s13277-015-3663-0
Popis: Axillary lymph nodes status is the most important prognosis factor in early breast cancer. This status is known by a selective sentinel lymph node biopsy (SLNB) and/or lymphadenectomy. Immunohistochemical studies of breast cancer tumour tissue have reported a relation between the increased expression of vascular endothelial growth factor-C (VEGF-C) and the risk of lymph node metastasis. We researched whether serum levels of VEGF-C could be a predictor factor of sentinel lymph node status in these patients. A prospective analysis was performed on serum from 174 patients with early breast cancer who underwent SLNB. The level of VEGF-C was determined by enzyme-linked immunosorbent assay. Clinical-pathologic variables were collected. Univariate analysis and multivariate logistic regression were conducted, taking SLNB positivity as the segmentation variable. The predictive value of VEGF-C was assessed using ROC curves. Of the sample group of 167 patients, 64 (38.3 %) had affected lymph node. Eighteen patients (28.1 %) presented micrometastasis; there were isolated tumour cells in 11 cases (17.2 %) and macrometastasis in 35 (54.6 %). The median value of VEGF-C was 6561.5 pg/ml. These values did not correlate with any clinical variables, and there was no association between the level of VEGF-C and SLNB status (p = 0.626). In the multivariate analysis, tumour size (p = 0.009) and the presence of vascular invasion (p
Databáze: OpenAIRE
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