Clinical study of serum interleukin-6 in children with community-acquired pneumonia
| Autor: | Nermeen A. Whdan, Ahmed A Khattab, Muhammad Said El-Mekkawy, Amira M. F. Shehata |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty biology business.industry medicine.medical_treatment Organ dysfunction lcsh:RJ1-570 lcsh:Pediatrics Hypoxia (medical) medicine.disease 03 medical and health sciences Pneumonia 0302 clinical medicine Community-acquired pneumonia 030220 oncology & carcinogenesis Internal medicine Shock (circulatory) medicine biology.protein 030212 general & internal medicine medicine.symptom business Prospective cohort study Interleukin 6 |
| Zdroj: | Egyptian Pediatric Association Gazette, Vol 66, Iss 2, Pp 43-48 (2018) |
| ISSN: | 1110-6638 |
| DOI: | 10.1016/j.epag.2018.03.003 |
| Popis: | Background: Community-acquired pneumonia (CAP) is an important childhood killer. Excessive production of cytokines, including interleukin-6 (IL-6), might be associated with severe disease course but pediatric data is limited. Aim: To assess value of IL-6 in predicting CAP severity in children. Methods: A prospective study conducted on 73 children hospitalized for CAP and 15 healthy controls. Pneumonia severity was evaluated according to World Health Organization (WHO) classification, Respiratory Index of Severity Score (RISC), Predisposition, Insult, Response, Organ dysfunction modified (PIROm score), and Pediatric Respiratory Severity Score (PRESS). Serum IL-6 was measured within 24 h of admission. The primary outcome was occurrence of any pneumonia complications or death within 30 days. Results: IL-6 was significantly higher among patients compared with controls. Unlike CRP, IL-6 was significantly higher among children with severe pneumonia as determined by WHO, PRESS, and RISC (p = 0.001 for all). IL-6 was significantly higher among children with PICU admission, mechanical ventilation, shock (p = 0.001 for all), hypoxia (p |
| Databáze: | OpenAIRE |
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