Direct oral anticoagulant agents attenuate temporary aortic occlusion-induced renal oxidative and inflammatory responses in rats
| Autor: | Selim, Durmaz, Tünay, Kurtoğlu, Ömer Faruk, Rahman, Canten, Tataroğlu, Mustafa, Yılmaz, Emin, Barbarus, Muhammet Hüseyin, Erkan |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Turkish Journal of Thoracic and Cardiovascular Surgery. 30:184-191 |
| ISSN: | 2149-8156 1301-5680 |
| DOI: | 10.5606/tgkdc.dergisi.2022.22831 |
| Popis: | Background: This study aims to investigate the effects of different direct oral anticoagulants on experimental renal injury induced by temporary infrarenal aortic occlusion. Methods: A total of 35 male Wistar rats (250 to 350 g) were randomly allocated to any of the five groups: sham, ischemia-reperfusion, rivaroxaban, dabigatran, and apixaban groups. Sham group underwent median laparotomy. Ischemia-reperfusion group was given saline gavage for one week. Animals in the other groups received rivaroxaban (3 mg/kg), dabigatran (15 mg/kg), or apixaban (10 mg/kg) daily once for one week via oral gavage. The infrarenal abdominal aorta was clamped for 60 min, and reperfusion was maintained for 120 min in the ischemia-reperfusion, rivaroxaban, dabigatran, and apixaban groups. At the end of reperfusion, kidneys were harvested for biochemical and histopathological analysis. Results: Renal total antioxidant capacity was reduced, and total oxidant status, interleukin-1 beta, and tumor necrosis factor-alpha were elevated in the ischemia-reperfusion group, compared to the sham group (p Conclusion: Direct oral anticoagulants reduce aortic clamping-induced renal tissue oxidation and inflammation. Rivaroxaban and dabigatran attenuate ischemia-reperfusion-related histological damage in kidneys. |
| Databáze: | OpenAIRE |
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