Suspicious Prenasal Skin Thickness-to-Nasal Bone Length Ratio: Prevalence and Correlation with Other Markers in Second and Third Trimester Fetuses with Down Syndrome
| Autor: | Michael Entezami, M. Albig, Thomas Keller, A. Hagen, Markus Stumm |
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| Rok vydání: | 2015 |
| Předmět: |
Down syndrome
Pathology medicine.medical_specialty Pregnancy Trimester Third Statistics as Topic Third trimester Gastroenterology Skin thickness Sensitivity and Specificity Ultrasonography Prenatal Correlation Pregnancy Reference Values Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Nasal Bone Retrospective Studies Skin Fetus business.industry Infant Newborn Retrospective cohort study medicine.disease Nasal bone ROC Curve Pregnancy Trimester Second Gestation Female Down Syndrome business |
| Zdroj: | Ultraschall in der Medizin (Stuttgart, Germany : 1980). 36(5) |
| ISSN: | 1438-8782 |
| Popis: | To assess the prevalence and value of a suspicious prenasal skin thickness-to-nasal bone length ratio (PT/NB ratio) in comparison to other established markers in a large population of Down syndrome (DS) fetuses.This was a retrospective study of 139 DS fetuses and 530 normal fetuses scanned after 14 + 0 weeks of gestation. To characterize diagnostic performance, we used the ROC curve approach. The presence or absence of a PT/NB ratio 0.8 and 11 other markers were assessed in the group of DS fetuses. A correlation analysis was performed in order to investigate associations between PT/NB ratio and other markers.Among DS fetuses the median PT/NB ratio was 1.06 (IQR 0.729) and was significantly higher compared to normal fetuses with 0.62 (IQR 0.148), (p 0.001). Gestational age had no influence on the PT/NB ratio. A PT/NB ratio 0.8 had the highest prevalence of all markers with 89.2 % in the group of DS fetuses, 3 cases were negative for all markers and 3 cases were positive only for PT/NB ratio 0.8. Marker-specific comparison between prevalences of a suspicious PT/NB ratio with respect to the presence or absence of other markers was statistically significant for hypoplastic NB and major anomalies (p 0.05). Utilization of at least one of the following five markers was sufficient for detecting 136 out of 139 fetuses with trisomy 21: suspicious PT/NB ratio, hypoplastic NB, nuchal fold thickness, white spot, shortened femur.The PT/NB ratio is one of the most powerful indicators of DS in the second trimester. It is objective to interpret, easy to measure, and is reproducible. |
| Databáze: | OpenAIRE |
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