Neural response to stress and perceived stress differ in patients with left temporal lobe epilepsy
Autor: | Adam M. Goodman, Basia A. Szaflarski, Jane B. Allendorfer, Erik Nelson, Heidi Heyse, James C. Eliassen, Judd M. Storrs, Jerzy P. Szaflarski |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Cortisol secretion medicine.medical_specialty Hydrocortisone Hippocampus Audiology Hippocampal formation behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences Epilepsy 0302 clinical medicine Neuroimaging Heart Rate Humans Medicine 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Saliva Research Articles Radiological and Ultrasound Technology medicine.diagnostic_test business.industry 05 social sciences Stressor Middle Aged medicine.disease Magnetic Resonance Imaging Temporal Lobe medicine.anatomical_structure Epilepsy Temporal Lobe Neurology Female Neurology (clinical) Anatomy business Functional magnetic resonance imaging Stress Psychological 030217 neurology & neurosurgery Parahippocampal gyrus |
Zdroj: | Hum Brain Mapp |
ISSN: | 1097-0193 1065-9471 |
Popis: | Patients with epilepsy are often able to predict seizure occurrence subsequent to an acute stress experience. However, neuroimaging investigations into the neural basis of this relationship or the potential influence of perceived life stress are limited. The current study assessed the relationship between perceived stress and the neurobehavioral response to stress in patients with left temporal lobe epilepsy (LTLE) and healthy controls (HCs) using heart rate, salivary cortisol level, and functional magnetic resonance imaging and compared these effects between HCs and LTLE. Matched on perceived stress levels, groups of 36 patients with LTLE and 36 HCs completed the Montreal Imaging Stress Task, with control and stress math task conditions. Among LTLEs, 27 reported that prior (acute) stress affected their seizures (LTLES+), while nine did not (LTLES−). The results revealed that increased perceived stress was associated with seizure frequency in LTLE. Further, cortisol secretion was greater in LTLE, but did not vary with perceived stress as observed in HCs. A linear mixed‐effects analysis revealed that as perceived stress increased, activation in the hippocampal complex (parahippocampal gyrus and hippocampus) decreased during stressful math in the LTLES+, increased in HCs, but did not vary in the LTLES−. Task‐based functional connectivity analyses revealed LTLE differences in hippocampal functional connectivity with sensory cortex specific to stressor modalities. We argue that the current study demonstrates an inhibitory hippocampal mechanism underlying differences in resilience to stress between HCs and LTLE, as well as LTLE patients who report stress as a precipitant of seizures. |
Databáze: | OpenAIRE |
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