A study of cell proliferation kinetics in the small intestinal epithelium of psoriasis patients
| Autor: | L. Hendel, Jørgen K. Larsen, Thorkil Ammitzbøll, G. Asboe-Hansen |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Kinetics Crypt Dermatology Biology Epithelium chemistry.chemical_compound Labelling Psoriasis Intestine Small medicine Humans Intestinal Mucosa Cell growth Compartment (ship) Middle Aged medicine.disease medicine.anatomical_structure chemistry Female Thymidine Cell Division |
| Zdroj: | Clinical and Experimental Dermatology. 9:329-335 |
| ISSN: | 1365-2230 0307-6938 |
| DOI: | 10.1111/j.1365-2230.1984.tb00812.x |
| Popis: | Summary Small intestinal biopsies from psoriasis patients and from nonnal controls were obtained with a multipurpose suction tube. The tissue was incubated with tritiated thymidine and processed for autoradiography. Labelling indices (LI) were calculated by counting labelled cells in all crypt cross-sections through the entire proliferative compartment. LI was increased in psoriatics as compared to controls indicating alterations in small intestinal epithelial cell kinetics in psoriasis. A continuous labelling allowing us to calculate the S-phase duration and the total cell turnover time was probably not obtained within an experimental period. |
| Databáze: | OpenAIRE |
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