Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial
| Autor: | Veronique G.J.M. VanderHorst, Lewis A. Lipsitz, Jeffrey M. Hausdorff, Natalia Gouskova, Nir Giladi, Talia Herman, Alvaro Pascual-Leone, Brad Manor, Thomas G. Travison, Moria Dagan |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease genetic structures medicine.medical_treatment Prefrontal Cortex Stimulation Transcranial Direct Current Stimulation law.invention Physical medicine and rehabilitation Double-Blind Method Randomized controlled trial law Humans Daily living Medicine Gait Gait Disorders Neurologic Transcranial direct-current stimulation business.industry Motor Cortex Parkinson Disease medicine.disease Neurology Test performance Neurology (clinical) Primary motor cortex business |
| Zdroj: | Movement Disorders. 36:2693-2698 |
| ISSN: | 1531-8257 0885-3185 |
| Popis: | Background Treatments of freezing of gait (FOG) in Parkinson's disease are suboptimal. Objective The aim of this study was to evaluate the effects of multiple sessions of transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex and primary motor cortex (M1) on FOG. Methods Seventy-seven individuals with Parkinson's disease and FOG were enrolled in a double-blinded randomized trial. tDCS and sham interventions comprised 10 sessions over 2 weeks followed by five once-weekly sessions. FOG-provoking test performance (primary outcome), functional outcomes, and self-reported FOG severity were assessed. Results Primary analyses demonstrated no advantage for tDCS in the FOG-provoking test. In secondary analyses, tDCS, compared with sham, decreased self-reported FOG severity and increased daily living step counts. Among individuals with mild-to-moderate FOG severity, tDCS improved FOG-provoking test time and self-report of FOG. Conclusions Multisession tDCS targeting the left dorsolateral prefrontal cortex and M1 did not improve laboratory-based FOG-provoking test performance. Improvements observed in participants with mild-to-moderate FOG severity warrant further investigation. © 2021 International Parkinson and Movement Disorder Society. |
| Databáze: | OpenAIRE |
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