Effects of programmed death ligand 1 on the prognosis of neuroblastoma
| Autor: | Fenggui Wei, Zelin Wu, Yawei Zou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Cell Survival education MEDLINE Scopus B7-H1 Antigen neuroblastoma 03 medical and health sciences 0302 clinical medicine Neuroblastoma Internal medicine Study Protocol Systematic Review medicine Humans protocol 030212 general & internal medicine Protocol (science) Cell Death business.industry Hazard ratio DNA Neoplasm General Medicine Prognosis medicine.disease Confidence interval Gene Expression Regulation Neoplastic meta-analysis programmed death ligand 1 030220 oncology & carcinogenesis Meta-analysis business Research Article Programmed death |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000024920 |
| Popis: | Background: Previous studies have investigated the prognostic role of programmed death ligand 1 (PD-L1) expression in patients with neuroblastoma, while the results are still controversial. Therefore, we conducted a meta-analysis to clarify the relationship between the expression of PD-L1 and the prognosis of neuroblastoma. Methods: Search electronic databases include PubMed, Cochrane, Embase, Scopus and Web of Science, and the search time is set to build the database until January 2021. Hazard ratio (HR) and 95% confidence interval (CI) were used to analyze the included results. Meta-analysis was performed using Stata 15.0 software. Results: This review will be disseminated in print by peer-review. Conclusion: The study will provide updated evidence for the evaluation of whether the expression of PD-L1 is associated with poor prognosis in patients with neuroblastoma. Ethics and dissemination: The private information from individuals will not be published. This systematic review also should not damage participants’ rights. Ethical approval is not available. The results may be published in a peer-reviewed journal or disseminated in relevant conferences OSF Registration number: DOI 10.17605/OSF.IO/FBCY6. |
| Databáze: | OpenAIRE |
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