Distinguishing early-stage nasopharyngeal carcinoma from benign hyperplasia using intravoxel incoherent motion diffusion-weighted MRI
| Autor: | Brigette B.Y. Ma, K.C. Allen Chan, Janet S.M. Chan, Anil T. Ahuja, Jing Yuan, Ann D. King, Edwin P. Hui, Weitian Chen, John K. S. Woo, Benny Zee, Darren M.C. Poon, Alexander C. Vlantis, Qi-Yong Ai, Anthony T.C. Chan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Stage (cooking) Intravoxel incoherent motion Early Detection of Cancer Aged Neoplasm Staging Aged 80 and over Hyperplasia Nasopharyngeal Carcinoma Receiver operating characteristic business.industry Area under the curve Reproducibility of Results Nasopharyngeal Neoplasms General Medicine Middle Aged medicine.disease Diffusion Magnetic Resonance Imaging Nasopharyngeal Diseases Nasopharyngeal carcinoma ROC Curve 030220 oncology & carcinogenesis Female Radiology business Diffusion MRI |
| Zdroj: | European radiology. 29(10) |
| ISSN: | 1432-1084 |
| Popis: | MRI can detect early-stage nasopharyngeal carcinoma (NPC), but the detection is more challenging in early-stage NPCs because they must be distinguished from benign hyperplasia in the nasopharynx. This study aimed to determine whether intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) MRI could distinguish between these two entities. Thirty-four subjects with early-stage NPC and 30 subjects with benign hyperplasia prospectively underwent IVIM DWI. The mean pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) values were calculated for all subjects and compared between the 2 groups using Student’s t test. Receiver operating characteristics with the area under the curve (AUC) was used to identify the optimal threshold for all significant parameters, and the corresponding diagnostic performance was calculated. A p value of |
| Databáze: | OpenAIRE |
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