One-Year Duration of Immunity Induced by Vaccination with a Canine Lyme Disease Bacterin
| Autor: | Thomas F. Warner, Terri Lee Wasmoen, Rhonda Lafleur, Jennifer C. Dant, Steven M. Callister, Steven D. Lovrich, Ronald F. Schell, Dean A. Jobe |
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| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Time Factors Biopsy Clinical Biochemistry Immunology Placebos Dogs Lyme disease medicine Animals Immunology and Allergy Dog Diseases Borrelia burgdorferi Arthritis Infectious Lyme Disease Ixodes medicine.diagnostic_test biology business.industry Lyme Disease Vaccines Skin Diseases Bacterial bacterial infections and mycoses Vaccine Research biology.organism_classification medicine.disease Antibodies Bacterial LYME Vaccination Lameness Skin biopsy Bacterial antigen business |
| Zdroj: | Clinical and Vaccine Immunology. 17:870-874 |
| ISSN: | 1556-679X 1556-6811 |
| DOI: | 10.1128/cvi.00524-09 |
| Popis: | Laboratory-reared beagles were vaccinated with a placebo or a bacterin comprised of Borrelia burgdorferi S-1-10 and ospA -negative/ ospB -negative B. burgdorferi 50772 and challenged after 1 year with B. burgdorferi -infected Ixodes scapularis ticks. For the placebo recipients, spirochetes were recovered from 9 (60%) skin biopsy specimens collected after 1 month, and the organisms persisted in the skin thereafter. Ten (67%) dogs also developed joint infection (3 dogs), lameness or synovitis (7 dogs), or B. burgdorferi -specific antibodies (8 dogs). For the vaccine recipients, spirochetes were recovered from 6 (40%) skin biopsy specimens collected after 1 month. However, subsequent biopsy specimens were negative, and the dogs failed to develop joint infection ( P = 0.224), lameness/synovitis ( P = 0.006), or Lyme disease-specific antibody responses ( P = 0.002). The bacterin provided a high level of protection for 1 year after immunization, and the addition of the OspC-producing B. burgdorferi 50772 provided enhanced protection. |
| Databáze: | OpenAIRE |
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