Intraocular pressure and glycosaminoglycan distribution in the rabbit eye: Effect of age and dexamethasone
| Autor: | Moira Breen, Paul A. Knepper, Lawrence J. Blacik, H.G. Weinstein |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Aging medicine.medical_specialty Intraocular pressure genetic structures Keratan sulfate Eye Dexamethasone Glycosaminoglycan Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Chondroitin sulfate Iris (anatomy) Intraocular Pressure Glycosaminoglycans biology Body Weight eye diseases Sensory Systems Sclera Surgery carbohydrates (lipids) Ophthalmology Endocrinology medicine.anatomical_structure chemistry Proteoglycan biology.protein Female Rabbits sense organs medicine.drug |
| Zdroj: | Experimental Eye Research. 27:567-575 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/0014-4835(78)90141-0 |
| Popis: | The effect of dexamethasone on intraocular pressure was studied in young and old rabbits and was related to the concentration and distribution of the glycosaminoglycans obtained from the proteoglycan in the anterior segment of the eye (central cornea, peripheral cornea, sclera and iris). Topical application of dexamethasone resulted in an increase of intraocular pressure of young rabbits but had no effect on the intraocular pressure of old rabbits. The changes in the relative distribution of the glycosaminoglycans components were observed as a function of age and/or dexamethasone treatment. The ratio of non-uronic acid containing glycosaminoglycans (keratan sulfate) to the uronic acid containing glycosaminoglycans decreased with age and was reversed by dexamethasone treatment of the aged animal. Thus, the distribution of the glycosaminoglycans induced by dexamethasone treatment may modulate intraocular pressure. |
| Databáze: | OpenAIRE |
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