Multimodal Cognitive Enhancement Therapy for Patients with Mild Cognitive Impairment and Mild Dementia: A Multi- Center, Randomized, Controlled, Double-Blind, Crossover Trial
| Autor: | Hye Jin Byun, Ji Won Han, Jong Chul Youn, Chi-Un Pae, Kayoung Kim, Taehyun Kim, Ji Won Ko, Jong Woo Hong, Ki Woong Kim, Seungho Ryu, Nam Jin Lee, Hyeonggon Lee |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Clinical Dementia Rating medicine.medical_treatment law.invention 03 medical and health sciences 0302 clinical medicine Reminiscence therapy Randomized controlled trial Double-Blind Method law Outcome Assessment Health Care Medicine Dementia Humans Cognitive Dysfunction 030212 general & internal medicine Aged Aged 80 and over Psychiatric Status Rating Scales Cross-Over Studies Cognitive Behavioral Therapy business.industry General Neuroscience Cognition General Medicine medicine.disease Crossover study Cognitive training Psychiatry and Mental health Clinical Psychology Cognitive therapy Physical therapy Female Geriatrics and Gerontology business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Alzheimer's disease : JAD. 55(2) |
| ISSN: | 1875-8908 |
| Popis: | We developed and evaluated the effect of Multimodal Cognitive Enhancement Therapy (MCET) consisting of cognitive training, cognitive stimulations, reality orientation, physical therapy, reminiscence therapy, and music therapy in combination in older people with mild cognitive impairment (MCI) or mild dementia. This study was a multi-center, double-blind, randomized, placebo-controlled, two-period cross-over study (two 8-week treatment phases separated by a 4-week wash-out period). Sixty-four participants with MCI or dementia whose Clinical Dementia Rating was 0.5 or 1 were randomized to the MCET group or the mock-therapy (placebo) group. Outcomes were measured at baseline, week 9, and week 21. Fifty-five patients completed the study. Mini-Mental State Examination (effect size = 0.47, p = 0.013) and Alzheimer's Disease Assessment Scale-Cognitive Subscale (effect size = 0.35, p = 0.045) scores were significantly improved in the MCET compared with mock-therapy group. Revised Memory and Behavior Problems Checklist frequency (effect size = 0.38, p = 0.046) and self-rated Quality of Life - Alzheimer's Disease (effect size = 0.39, p = 0.047) scores were significantly improved in the MCET compared with mock-therapy. MCET improved cognition, behavior, and quality of life in people with MCI or mild dementia more effectively than conventional cognitive enhancing activities did. |
| Databáze: | OpenAIRE |
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