Necrotic Primary Central Nervous System Lymphoma in an Immunocompetent Patient: A Case Report and Literature Review
| Autor: | Dinesh S. Rao, Peter Fiester, Dalys Haymes, Erik Soule, Patrick Natter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Central nervous system Neurosurgery Computed tomography Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases diffusion weighted imaging Medicine magnetic resonance imaging medicine.diagnostic_test primary central nervous system lymphoma business.industry General Engineering Primary central nervous system lymphoma Magnetic resonance imaging computed tomography medicine.disease immunocompetent Lymphoma medicine.anatomical_structure Oncology Homogeneous business Radiology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Primary lymphoma that arises de novo from the central nervous system (CNS) is most commonly a non-Hodgkin's B-cell lymphoma and by definition lacks the presence of disease outside the CNS. It demonstrates a characteristic imaging appearance on computed tomography (CT) and magnetic resonance imaging (MRI) exams related to its inherent hypercellularity. On CT, primary CNS lymphoma (PCNSL) demonstrates a hyperdense appearance; on MRI, it commonly demonstrates restricted water diffusion on diffusion-weighted sequences and homogeneous enhancement on post-contrast sequences. We present a case of primary CNS lymphoma in an immunocompetent patient with progressive necrosis and loss of restricted diffusion on diffusion-weighted imaging (DWI) with an atypical enhancement pattern. We further provide a review of the literature regarding the CT and MRI appearance of primary CNS lymphoma and discuss the role of immune status in determining the imaging characteristics of this disease process. |
| Databáze: | OpenAIRE |
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