Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins
| Autor: | Hendrik Kersten, Thorsten Benter, Edward P. C. Lai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Bisphenol A endocrine system Formates Electrospray ionization Pharmaceutical Science 02 engineering and technology 010501 environmental sciences 01 natural sciences Mass Spectrometry Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Adsorption Phenols lcsh:Organic chemistry Desorption Drug Discovery Animals Benzhydryl Compounds Physical and Theoretical Chemistry milk whey proteins sodium formate ion-trap mass spectrometry 0105 earth and related environmental sciences Titanium Chromatography Curdling Sodium formate urogenital system bisphenol a Organic Chemistry technology industry and agriculture Milk Proteins 021001 nanoscience & nanotechnology 6. Clean water Milk chemistry 13. Climate action Chemistry (miscellaneous) Nanoparticles Molecular Medicine Ion trap 0210 nano-technology titanium dioxide nanoparticles Quantitative analysis (chemistry) hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecules, Vol 25, Iss 3, p 708 (2020) Molecules Volume 25 Issue 3 |
| ISSN: | 1420-3049 |
| Popis: | Quantitative analysis of endocrine-disrupting molecules such as bisphenol A (BPA) in freshwater to determine their widespread occurrence in environmental resources has been challenged by various adsorption and desorption processes. In this work, ion trap mass spectrometry (ITMS) analysis of BPA was aimed at studying its molecular interactions with titanium dioxide (TiO2) nanoparticles and milk whey proteins. Addition of sodium formate prevented TiO2 nanoparticles from sedimentation while enhancing the electrospray ionization (ESI) efficiency to produce an abundance of [BPA + Na]+ ions at m/z 251.0. More importantly, the ESI-ITMS instrument could operate properly during a direct infusion of nanoparticles up to 500 μg/mL without clogging the intake capillary. Milk protein adsorption of BPA could decrease the [BPA + Na]+ peak intensity significantly unless the proteins were partially removed by curdling to produce whey, which allowed BPA desorption during ESI for quantitative analysis by ITMS. |
| Databáze: | OpenAIRE |
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