Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease
| Autor: | Martina Pajková, Róbert Hromádka, Lucie Mikšátková, Veronika Antonyová, Michal Masařík, Robert Kaplánek, Veronika Talianová, Zdeněk Kejík, Tereza Brogyányi, Pavel Martásek, David Sýkora, Milan Jakubek |
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| Rok vydání: | 2020 |
| Předmět: |
Mitochondrial DNA
Parkinson's disease tau Proteins Disease Biology Complex ecosystem medicine.disease_cause Biochemistry DNA Mitochondrial Protein Aggregation Pathological Pathogenesis 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Humans Molecular Biology Neuroinflammation 030304 developmental biology Inflammation 0303 health sciences Amyloid beta-Peptides Parkinson Disease Cell Biology medicine.disease 030220 oncology & carcinogenesis Mutation alpha-Synuclein Neuroscience Oxidative stress Human mitochondrial DNA haplogroup DNA Damage |
| Zdroj: | DNA repair. |
| ISSN: | 1568-7856 |
| Popis: | Neurodegenerative diseases (e.g. Alzheimer's and Parkinson's disease) are becoming increasingly problematic to healthcare systems. Therefore, their underlying mechanisms are trending topics of study in medicinal research. Numerous studies have evidenced a strong association between mitochondrial DNA disturbances (e.g. oxidative damage, mutations, and methylation shifts) and the initiation and progression of neurodegenerative diseases. Therefore, this review discusses the risk and development of neurodegenerative diseases in terms of disturbances in mitochondrial DNA and as a part of a complex ecosystem that includes other important mechanisms (e.g. neuroinflammation and the misfolding and aggregation of amyloid-β peptides, α-synuclein, and tau proteins). In addition, the influence of individual mitochondrial DNA haplogroups on the risk and development of neurodegenerative diseases is also described and discussed. |
| Databáze: | OpenAIRE |
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