RADIOTHERAPY TUMOR CONTROL CUMULATIVE PROBABILITY 3D INTEGRAL EQUATION WITH TCP IMPROVED MODEL

Autor:	Casesnoves, Francisco
Rok vydání:	2023
Předmět:	Pareto-Multiobjective Optimization (PMO) Mathematical Methods (MM) Biological Models (BM) Radiation Therapy (RT) Initial Tumor Clonogenes Number Population ( N0) Effective Tumor Population Clonogenes Number ( NEffective ) Linear Quadratic Model (LQM) Integral Equation (IE) Tumor Control Probability (TCP) Normal Tissue Complications Probability (NTCP) Biological Effective model (BED) Tumor Control Cumulative Probability (TCCP) Radiation Photon-Dose (RPD) Nonlinear Optimization Radiotherapy Treatment Planning Optimization (TPO) Software Engineering Methods Radiation Photon-Dose
DOI:	10.5281/zenodo.7981321
Popis:	A triple-variableIntegral Equation for Tumor Control Cumulative Probability (TCCP)is developed with the addition of the important radiotherapy Treatment-Time parameter. Based on a previous double TCCP Integral Equation depending on Biological Model parameters (α, β ), the NEffective model is implemented in Tumor Control Probability (TCP)equation. Results comprise a TCCP Integral Equation model with three essential parameters for Radiation Therapy precise determination of TCCP.Solution shows the method to obtain a 3D Integral Equation of first kind.Results applicationscould involve better optimization for TCCP in radiotherapybiological models.Radiotherapy Treatment Planning Optimization (TPO) and Radioprotection consequences are explained.
Databáze:	OpenAIRE
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